GW28-e1107 Sestrin2 suppresses age-related hypertrophy by inhibiting mTORC1 signaling pathway
نویسندگان
چکیده
منابع مشابه
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag guanosine triphosphatases and their regulators GATOR1 and GATOR2. Sestrin2 interacts with GATOR2 and is a leucine sensor. Here we present the 2.7 angstrom crystal stru...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2017
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2017.07.182